Russia's largest scheduled cargo airline said it will operate the new route with a Boeing 747-400 from Moscow to Chicago's O'Hare International Airport via Amsterdam Schiphol Airport.
AirBridge, a division of the Volga-Dnepr group, is the first all-cargo carrier with regular service between Russia and the United States.
Menzies Aviation and Swissport will handle ground operations at O'Hare for AirBridge, which said it would open its own office in the United States by the end of the year.